Folate Receptor-Targeted Vinca Alkaloid EC0489
A folate receptor-targeting cytotoxic drug conjugate consisting of a folate vitamin analogue linked to a vinca alkaloid microtubule destabilizing agent with potential antineoplastic activity. Mediated through its folate moiety, folate receptor-targeted vinca alkaloid EC0489 delivers the cytotoxic vinca alkaloid moiety directly to cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the vinca alkaloid moiety binds to tubulin and disrupts microtubule assembly-disassembly dynamics, resulting in cell cycle arrest and apoptosis. The relative tumor cell specificity of this agent reduces the toxicity profile of its vinca alkaloid moiety. [ ]
Term info
Folate Receptor-Targeted Vinca Alkaloid EC0489
- EC0489
- Folate Receptor-Targeted Vinca Alkaloid EC0489
NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
CTRP
Folate Receptor-Targeted Vinca Alkaloid EC0489
http://purl.obolibrary.org/obo/NCIT_C17219
Folate_Receptor_Targeted-Microtubule_Destabilizing_Agent_EC0489
638649
638649
Folate Receptor-Targeted Vinca Alkaloid EC0489
Pharmacologic Substance, Organic Chemical
C2830054
C81935
Term relations
- Antineoplastic Enzyme Inhibitor
- Tubulin Binding Agent
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Microtubule Process
- Chemical_Or_Drug_Affects_Gene_Product some Tubulin
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Mitosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of G2 to M Transition