Terminology Service for NFDI4Health
JSON

Suramin

Go to external page http://purl.obolibrary.org/obo/NCIT_C853

A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04) [ ]

Term info

Label

Suramin

Synonyms
  • SURAMIN
  • Suramin
  • suramin
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A drug that is used to treat infections caused by parasites. It is also being studied in the treatment of cancer. It belongs to the families of drugs called antiprotozoals and anthelmintics.

Accepted Therapeutic Use For

Trypanosomiasis; hormone-refractory prostate cancer

CAS Registry

145-63-1

CHEBI ID

CHEBI:45906

Chemical Formula

C51H40N6O23S6

Display Name

Suramin

FDA UNII Code

6032D45BEM

Has Salt Form

http://purl.obolibrary.org/obo/NCIT_C1848

Preferred Name

Suramin

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0038880

code

C853