Terminology Service for NFDI4Health
Gamma Secretase
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http://purl.obolibrary.org/obo/NCIT_C95114
A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein. [ ]
Term info
Label
Gamma Secretase
Synonyms
- Gamma Secretase
- Gamma-Secretase
DesignNote
The components required for the enzymatic activity of gamma secretase are a homodimer of presenilin (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. The proteolytic activity appears to be mediated by presenilin, while the other proteins are required for both stabilization of the active form of presenilin and localization of the complex.
Preferred Name
Gamma Secretase
Semantic Type
Amino Acid, Peptide, or Protein, Enzyme
UMLS CUI
C0379528
code
C95114
Term relations
Subclass of:
- Protein or Riboprotein Complex
- Gene_Product_Is_Element_In_Pathway some Syndecan-3-Mediated Signaling Pathway
- Gene_Product_Plays_Role_In_Biological_Process some Proteolysis
- Gene_Product_Is_Element_In_Pathway some Nerve Growth Factor Receptor Signaling Pathway
- Gene_Product_Is_Element_In_Pathway some Presenilin Action in Notch and Wnt Signaling Pathways
- Gene_Product_Is_Element_In_Pathway some Notch and Wnt Signaling Pathway
- Gene_Product_Plays_Role_In_Biological_Process some Signal Transduction
- Gene_Product_Is_Element_In_Pathway some Segmentation Clock Pathway
- Gene_Product_Is_Element_In_Pathway some Gamma-Secretase Mediated ErbB4 Signaling Pathway
- Gene_Product_Is_Element_In_Pathway some Amyloid Beta-Peptide Pathway
- Gene_Product_Is_Element_In_Pathway some ERBB4 Signaling Pathway