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Saracatinib Difumarate

Go to external page http://purl.obolibrary.org/obo/NCIT_C95224

The difumarate salt of saracatinib, an orally available 5-, 7-substituted anilinoquinazoline with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor of Src and Abl, protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. This agent binds to and inhibits these tyrosine kinases and affects cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption. [ ]

Term info

Label

Saracatinib Difumarate

Synonyms
  • 4-Quinazolinamine, N-(5-Chloro-1,3-Benzodioxol-4-yl)-7-(2-(4-Methyl-1-Piperazinyl)Ethoxy)-5-((Tetrahydro-2H-Pyran-4-yl)Oxy)-, (2e)-2-Butenedioate (1:2)
  • AZD-0530 Difumarate
  • AZD0530 Difumarate
  • N-(5-Chloro-1,3-Benzodioxol-4-yl)-7-(2-(4-Methylpiperazin-1-yl)Ethoxy)-5-(Tetrahydro-2H-Pyran-4-yloxy)Quinazolin-4-Amine Di((2e)-but-2-Enedioate)
  • SARACATINIB DIFUMARATE
  • Saracatinib Difumarate
Subsets

NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C157712

CAS Registry

893428-72-3

Chemical Formula

C27H32ClN5O5.2C4H4O4

FDA UNII Code

8R1DYT4EAW

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C48378

Preferred Name

Saracatinib Difumarate

Semantic Type

Pharmacologic Substance

UMLS CUI

C2987006

code

C95224