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Selumetinib Sulfate

Go to external page http://purl.obolibrary.org/obo/NCIT_C95225

The sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers. [ ]

Term info

Label

Selumetinib Sulfate

Synonyms
  • 1H-Benzimidazole-6-Carboxamide, 5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-N-(2- Hydroxyethoxy)-1-Methyl-, Sulfate (1:1)
  • 1h-Benzimidazole-6-Carboxamide,5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-N-(2- Hydroxyethoxy)-1-Methyl-, Sulphate (1:1)
  • 5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H- Benzimidazole-6-Carboxamide Sulfate
  • 5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H- Benzimidazole-6-Carboxamide Sulphate
  • AZD-6244 Hydrogen Sulfate
  • AZD6244 Hydrogen Sulfate
  • AZD6244 Hydrogen Sulphate
  • SELUMETINIB SULFATE
  • Selumetinib Sulfate
  • Selumetinib Sulphate
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

CAS Registry

943332-08-9

Chemical Formula

C17H15BrClFN4O3.H2O4S

Display Name

Selumetinib Sulfate

FDA UNII Code

807ME4B7IJ

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C66939

Has Target

http://purl.obolibrary.org/obo/NCIT_C26486

Preferred Name

Selumetinib Sulfate

Semantic Type

Pharmacologic Substance

UMLS CUI

C2987007

code

C95225