Terminology Service for NFDI4Health
JSON

Varlitinib Tosylate

Go to external page http://purl.obolibrary.org/obo/NCIT_C95226

The tosylate salt form of varlitinib, an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone. [ ]

Term info

Label

Varlitinib Tosylate

Synonyms
  • 4,6-Quinazolinediamine, N(Sup 4)-(3-Chloro-4-(2-Thiazolylmethoxy)Phenyl)-N(Sup 6)-((4r)-4,5-Dihydro-4-Methyl-2-Oxazolyl)-, 4-Methylbenzenesulphonate (1:2)
  • 4-N-(3-Chloro-4-(Thiazol-2-Ylmethoxy)Phenyl)-6-N-((4r)-4-Methyl-4,5-Dihydrooxazol-2- Yl)Quinazoline-4,6-Diamine Bis(4-Methylbenzenesulphonate)
  • AR00334543 Ditosilate
  • AR00334543 Ditosylate
  • ARRY-334543 Ditosylate
  • ARRY-543 Ditosilate
  • ARRY-543 Ditosylate
  • VARLITINIB TOSYLATE
  • Varlitinib Tosylate
Subsets

NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C157712

CAS Registry

1146629-86-8

Chemical Formula

C22H19ClN6O2S.2C7H8O3S

FDA UNII Code

V4M8FWS152

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C62530

Has Target

http://purl.obolibrary.org/obo/NCIT_C17068

Preferred Name

Varlitinib Tosylate

Semantic Type

Pharmacologic Substance

UMLS CUI

C2987008

code

C95226