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Puromycin-Sensitive Aminopeptidase

Go to external page http://purl.obolibrary.org/obo/NCIT_C95861

Puromycin-sensitive aminopeptidase (919 aa, ~103 kDa) is encoded by the human NPEPPS gene. This protein plays a role in peptide cleavage. [ ]

Term info

Label

Puromycin-Sensitive Aminopeptidase

Synonyms
  • AAP-S
  • Cytosol Alanyl Aminopeptidase
  • EC 3.4.11.14
  • PSA
  • Puromycin-Sensitive Aminopeptidase
DesignNote

Puromycin-sensitive aminopeptidase may have hyperphosphorylated tau as a substrate. Enhancement of the activity of the enzyme is a candidate therapy for neuropathies where tau accumulation occurs, such as Alzheimer disease. (Hum. Mol. Genet. 2011; 20: doi: 10.1093/hmg/ddr065.)

OMIM Number

606793

Preferred Name

Puromycin-Sensitive Aminopeptidase

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

Swiss Prot

P55786

UMLS CUI

C0139360

code

C95861