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Gemcitabine Hydrochloride

Go to external page http://purl.obolibrary.org/obo/NCIT_C961

The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. [ ]

Term info

Label

Gemcitabine Hydrochloride

Synonyms
  • 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride
  • 2'Deoxy-2',2'-Difluorocytidine, Hydrochloride
  • Difluorodeoxycytidine Hydrochloride
  • FF 10832
  • FF-10832
  • FF10832
  • GEMCITABINE HYDROCHLORIDE
  • Gemcitabine HCI
  • Gemcitabine Hydrochloride
  • Gemzar
  • LY-188011
  • LY188011
  • dFdCyd
  • gemcitabine hydrochloride
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A drug used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine hydrochloride blocks the cell from making DNA and may kill cancer cells.

Accepted Therapeutic Use For

Bladder cancer; Breast cancer; Carcinoma of unknown primary origin; Lung cancer; including non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Renal cell carcinoma

CAS Registry

122111-03-9

CHEBI ID

CHEBI:31647

Chemical Formula

C9H11F2N3O4.HCl

Display Name

Gemcitabine Hydrochloride

FDA UNII Code

U347PV74IL

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C66876

Legacy Concept Name

Gemcitabine

NSC Code

613327

Preferred Name

Gemcitabine Hydrochloride

Semantic Type

Pharmacologic Substance, Nucleic Acid, Nucleoside, or Nucleotide

UMLS CUI

C0771488

code

C961

Term relations

Related from:
Chemotherapy_Regimen_Has_Component