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Prelamin-A/C

Go to external page http://purl.obolibrary.org/obo/NCIT_C96447

Prelamin-A/C (664 aa, ~74 kDa) is encoded by the human LMNA gene. This protein is involved in the framework required for the nuclear envelope and in chromatin interactions. [ ]

Term info

Label

Prelamin-A/C

Synonyms
  • LMNA
  • Lamin-A/C Precursor
  • Prelamin A
  • Prelamin A/C
  • Prelamin-A
  • Prelamin-A/C
  • Renal Carcinoma Antigen NY-REN-32 Precursor
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Prelamin-A/C must be farnesylated before it can be proteolytically processed by CAAX prenyl protease 1 homolog to remove 3 C-terminal and then must be methylated before it can be proteolytically processed to remove 15 C-terminal residues to yield lamin-A/C., UniProt considers prelamin-A the canonical sequence; prelamin-C (572 aa, ~65 kDa) has a different amino acid sequence at residues 567-572 and is missing residues 573-664.

Display Name

Prelamin-A/C

OMIM Number

150330

Preferred Name

Prelamin-A/C

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

P02545

UMLS CUI

C3272784

code

C96447