Verubulin
A quinazoline derivative with potential antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, and may be useful for treating multidrug resistant tumors. In addition, as a vascular disrupting agent, verubulin disrupts tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death. In addition, verubulin is able to cross the blood-brain barrier and accumulate in the brain. [ ]
Term info
Verubulin
- 4-quinazolinamine, N-(4-methoxyphenyl)-N,2-dimethyl-
- MX-128495
- N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine
- VERUBULIN
- Verubulin
NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C157712
827031-83-4
C17H17N3O
X97O9FTB92
http://purl.obolibrary.org/obo/NCIT_C64782
http://purl.obolibrary.org/obo/NCIT_C17219
Verubulin
Pharmacologic Substance, Organic Chemical
C2002404
C96747
Term relations
- Tubulin Binding Agent
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Microtubule Process
- Chemical_Or_Drug_Affects_Gene_Product some Tubulin
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Mitosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of G2 to M Transition