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Eribulin

Go to external page http://purl.obolibrary.org/obo/NCIT_C96748

An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. [ ]

Term info

Label

Eribulin

Synonyms
  • 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one
  • ER-086526
  • ERIBULIN
  • Eribulin
Subsets

NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C157712

CAS Registry

253128-41-5

CHEBI ID

CHEBI:63587

Chemical Formula

C40H59NO11

FDA UNII Code

LR24G6354G

Has Salt Form

http://purl.obolibrary.org/obo/NCIT_C26644

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

Preferred Name

Eribulin

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C2350866

code

C96748