Terminology Service for NFDI4Health

Iso-fludelone

Go to external page http://purl.obolibrary.org/obo/NCIT_C97332


A third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as well as reduced toxicity. In addition, this agent is a not a substrate of the P-glycoprotein (P-gp), a multidrug resistance pump often overexpressed in cancer cells. [ ]

Term info

Label

Iso-fludelone

Synonyms
  • 17-Iso-oxazole-26-F3-9,10-dehydro-12,13-desoxy-epothilone B
  • 17-Iso-oxazole-fludelone
  • Iso-fludelone
  • KOS-1803
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

Display Name

Iso-fludelone

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

NCI META CUI

CL429824

Preferred Name

Iso-fludelone

Semantic Type

Pharmacologic Substance, Organic Chemical

code

C97332