Terminology Service for NFDI4Health
MLL/AFF1 Fusion Gene
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http://purl.obolibrary.org/obo/NCIT_C99319
A fusion gene (~12 kb) that results from a chromosomal translocation t(4;11)(q21;q23) which fuses the 5' half of the MLL gene to the 3' half of the AFF1 gene. This rearrangement is associated with acute lymphocytic leukemia and other leukemia types. [ ]
Term info
Label
MLL/AFF1 Fusion Gene
Synonyms
- MLL-AF4 Fusion Gene
- MLL-AFF1 Fusion Gene
- MLL-MLLT2 Fusion Gene
- MLL/AF4 Fusion Gene
- MLL/AFF1 Fusion Gene
- MLL/MLLT2 Fusion Gene
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
The presence of this fusion gene is associated with a very poor prognosis.
Display Name
MLL/AFF1 Fusion Gene
Preferred Name
MLL/AFF1 Fusion Gene
Related To Genetic Biomarker
http://purl.obolibrary.org/obo/NCIT_C24602, http://purl.obolibrary.org/obo/NCIT_C18585
Semantic Type
Gene or Genome
UMLS CUI
C2674774
code
C99319
Term relations
Subclass of:
- Fusion Gene
- Gene_Has_Abnormality some t(4;11)(q21;q23)
- Gene_Involved_In_Pathogenesis_Of_Disease some B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged
- Gene_Involved_In_Pathogenesis_Of_Disease some B Acute Lymphoblastic Leukemia with t(4;11)(q21;23)
- Gene_Involved_In_Pathogenesis_Of_Disease some Acute Myeloid Leukemia with Variant MLL Translocations