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MLL/MLLT3 Fusion Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C99323

A fusion gene that results from a chromosomal translocation t(9;11)(p22;q23) which fuses the 5' half of the MLL gene to the 3' end of the MLLT3 gene. This rearrangement is associated with acute lymphocytic leukemia and other leukemia types. [ ]

Term info

Label

MLL/MLLT3 Fusion Gene

Synonyms
  • MLL-AF9 Fusion Gene
  • MLL-MLLT3 Fusion Gene
  • MLL/AF9 Fusion Gene
  • MLL/MLLT3 Fusion Gene
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The presence of this fusion gene is associated with a better prognosis for primary leukemia as compared to other 11q23 fusions but it indicates a poor prognosis for secondary cases. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)

Display Name

MLL/MLLT3 Fusion Gene

Preferred Name

MLL/MLLT3 Fusion Gene

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C24603, http://purl.obolibrary.org/obo/NCIT_C18585

Semantic Type

Gene or Genome

UMLS CUI

C3274681

code

C99323