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CCND1/IGHG1 Fusion Gene

Go to external page http://purl.obolibrary.org/obo/NCIT_C99367

A fusion gene that results from a chromosomal translocation t(11;14)(q13;q32) which places the CCND1 gene on the 5' side of the joining segment of the immunoglobulin G heavy chain locus IGHG1 gene. This rearrangement is associated with numerous B-cell malignancies. [ ]

Term info

Label

CCND1/IGHG1 Fusion Gene

Synonyms
  • BCL1-IgH Fusion Gene
  • CCND1-IGHG1 Fusion Gene
  • CCND1/IGHG1 Fusion Gene
  • IGHG1/CCND1 Fusion Gene
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

This translocation allows the expression of the CCND1 gene to be controlled by the IgG heavy chain promoter, which causes overexpression of the G1/S-specific cyclin-D1 protein.

Display Name

CCND1/IGHG1 Fusion Gene

Preferred Name

CCND1/IGHG1 Fusion Gene

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C98020, http://purl.obolibrary.org/obo/NCIT_C18021

Semantic Type

Gene or Genome

UMLS CUI

C1868611

code

C99367

Term relations