Terminology Service for NFDI4Health

ETV6/JAK2 Fusion Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C99417


A fusion protein encoded by the ETV6/JAK2 fusion gene. This protein is comprised of the N-terminal half of the transcription factor ETV6 protein, including the pointed domain and the helix-loop-helix oligomerization domain, fused to the C-terminal tyrosine kinase domains of the tyrosine-protein kinase JAK2 protein. [ ]

Term info

Label

ETV6/JAK2 Fusion Protein

Synonyms
  • ETV6-JAK2 Fusion Protein
  • ETV6/JAK2 Fusion Protein
  • TEL/JAK2 Fusion Protein
  • Transcription Factor ETV6/Tyrosine-Protein Kinase JAK2 Fusion Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The helix-loop-helix domain of the transcription factor ETV6 protein may provide a dimerization interface for kinase domain of the tyrosine-protein kinase JAK2, which activates its tyrosine kinase activity. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)

Display Name

ETV6/JAK2 Fusion Protein

Preferred Name

ETV6/JAK2 Fusion Protein

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C18312, http://purl.obolibrary.org/obo/NCIT_C24529

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C1447569

code

C99417