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CRTC1/MAML2 Fusion Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C99742

A fusion protein (1024 aa, ~112 kDa) encoded by the CRTC1/MAML2 fusion gene. This protein is comprised of the first 42 N-terminal amino acids of the CREB-regulated transcription coactivator 1 protein fused to most of the mastermind-like protein 2. [ ]

Term info

Label

CRTC1/MAML2 Fusion Protein

Synonyms
  • CREB-Regulated Transcription Coactivator 1/Mastermind-Like Protein 2 Fusion Protein
  • CRTC1-MAML2 Fusion Oncoprotein
  • CRTC1/MAML2 Fusion Protein
  • MECT1/MAML2 Fusion Protein
  • TORC1-MAML2 Fusion Protein
  • WAMTP1-MAML2 Fusion Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The CRTC1/MAML2 fusion protein activates transcription of the Notch target gene HES1 independently of both Notch ligand and CSL. (Atlas of Genetics and Cytogenetics in Oncology and Haematology)

Display Name

CRTC1/MAML2 Fusion Protein

Preferred Name

CRTC1/MAML2 Fusion Protein

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C95449, http://purl.obolibrary.org/obo/NCIT_C95456

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C3274896

code

C99742