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PRKAR1A/RET Fusion Protein

Go to external page http://purl.obolibrary.org/obo/NCIT_C99846

A fusion protein encoded by the PRKAR1A/RET fusion gene. This protein is comprised of approximately 240 N-terminal amino acids of the cAMP-dependent protein kinase type I-alpha regulatory subunit protein, including a dimerization domain, fused with most of the C-terminal cytoplasmic domain of the proto-oncogene tyrosine-protein kinase receptor Ret protein, including the tyrosine kinase domain. [ ]

Term info

Label

PRKAR1A/RET Fusion Protein

Synonyms
  • PRKAR1A-RET Fusion Protein
  • PRKAR1A/RET Fusion Protein
  • PTC2 Chimeric Oncoprotein
  • PTC2-RET Fusion Protein
  • R1alpha/ret Fusion Protein
  • RIA-RET Fusion Protein
  • RIA/RET Fusion Protein
  • cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit/Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Fusion Protein
  • ret/PTC2 Oncoprotein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

The PRKAR1A/RET fusion protein is a constitutively dimerized and activated tyrosine kinase.

Display Name

PRKAR1A/RET Fusion Protein

Preferred Name

PRKAR1A/RET Fusion Protein

Related To Genetic Biomarker

http://purl.obolibrary.org/obo/NCIT_C18257, http://purl.obolibrary.org/obo/NCIT_C97742

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C3274999

code

C99846