Terminology Service for NFDI4Health
TPR/MET Fusion Protein
Go to external page
http://purl.obolibrary.org/obo/NCIT_C99863
A fusion protein (523 aa, ~60 kDa) encoded by the TPR/MET fusion gene. This protein is comprised of approximately 140 N-terminal amino acids of the nucleoprotein TPR, including two leucine zipper motifs, fused to the intracellular tyrosine kinase domain of the hepatocyte growth factor receptor protein. [ ]
Term info
Label
TPR/MET Fusion Protein
Synonyms
- Nucleoprotein TPR/Hepatocyte Growth Factor Receptor Fusion Protein
- TPR-MET Oncoprotein
- TPR/MET Fusion Protein
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
The TPR/MET fusion protein is a constitutively dimerized and activated tyrosine kinase.
Display Name
TPR/MET Fusion Protein
Preferred Name
TPR/MET Fusion Protein
Related To Genetic Biomarker
http://purl.obolibrary.org/obo/NCIT_C18325, http://purl.obolibrary.org/obo/NCIT_C97855
Semantic Type
Amino Acid, Peptide, or Protein
UMLS CUI
C0029011
code
C99863