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coelution assay measuring MHC ligand processing and presentation using T cell recognition of HPLC fractionated eluate compared to synthetic ligand

Go to external page http://purl.obolibrary.org/obo/OBI_0001500

A MHC ligand processing and presentation assay in which an HPL chromatography is run to separate an input mixture of ligands eluted from MHC into fractions. These fractions are tested for recognition by T cells and compared to the recognition of a synthetic ligand that is presumed to be the recognized epitope. Identical HPLC fractionation and T cell recognition patterns confirm that the specific ligand was presented by MHC molecules.

Term info

Label

coelution assay measuring MHC ligand processing and presentation using T cell recognition of HPLC fractionated eluate compared to synthetic ligand

IEDB alternative term

ligand presentation|coelution

editor preferred term

coelution assay measuring MHC ligand processing and presentation using T cell recognition of HPLC fractionated eluate compared to synthetic ligand

has curation status

http://purl.obolibrary.org/obo/IAO_0000120

term editor

PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters