Terminology Service for NFDI4Health
50% dissociation of binding temperature (Tm)
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http://purl.obolibrary.org/obo/OBI_0001566
A binding datum that specifies the temperature at which half of the binding partners are forming a complex and the other half are unbound.
Term info
Label
50% dissociation of binding temperature (Tm)
alternative term
melting temperature (Tm)
definition source
IEDB
editor preferred term
50% dissociation of binding temperature (Tm)
example of usage
Preparing a complex of a purified HLA-A*02:01 bound to a specific peptide ligand, varying the temperature while detecting the fraction of bound complexes with a complex conformation specific antibody, and interpolating the temperature at which 50% of complexes are dissociated.
has curation status
http://purl.obolibrary.org/obo/IAO_0000120
term editor
PERSON: Bjoern Peters, Randi Vita