Terminology Service for NFDI4Health
chromatin immunoprecipitation with exonuclease sequencing assay
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http://purl.obolibrary.org/obo/OBI_0001925
A ChIP-seq assay which uses immunoprecipitation to isolate protein bound DNA followed by an exonuclease step to degrade DNA that is not protein bound to provide greater resolution of the DNA binding site
Term info
Label
chromatin immunoprecipitation with exonuclease sequencing assay
alternative term
ChIP-exo assay
definition source
PMID:22153082
editor preferred term
chromatin immunoprecipitation with exonuclease sequencing assay
example of usage
Rhee et al. Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution. Cell. 2011 Dec;147(6):1408-19. [PMID:22153082]
has curation status
http://purl.obolibrary.org/obo/IAO_0000120
term editor
Venkat Malladi, Bjoern Peters, Chris Stoeckert, Jie Zheng
Term relations
Subclass of:
- ChIP-seq assay
- has_specified_output some DNA sequence data
- realizes some (
function and
inheres in some sonicator) and has_specified_input some sonicator - has part some specific enzymatic cleavage
- has part some cross linking