ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II regulatory region sequence-specific DNA binding (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN negative regulation of MHC class II biosynthetic process (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); protein autoubiquitination (ortholog); FOUND IN cytosol (ortholog); nucleolus (ortholog); nucleoplasm (ortholog); INTERACTS WITH 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil; amiodarone