Terminology Service for NFDI4Health
ciliary marginal zone
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http://purl.obolibrary.org/obo/UBERON_0003065
Region at the periphery of the retina where retinal stem cells are located. After 60 hpf, the CMZ is the source of most retinal growth.[Wehman et al, 2005] [ http://zfin.org/curator ]
Term info
Label
ciliary marginal zone
Synonyms
- peripheral growth zone
- retinal ciliary marginal zone
Subsets
uberon_slim, efo_slim
external definition
Region at the periphery of the retina where retinal stem cells are located. After 60 hpf, the CMZ is the source of most retinal growth. Wehman et al, 2005.[TAO]
has obo namespace
uberon
has related synonym
CMZ, retinal proliferative zone, circumferential germinal zone
homology notes
The retina of all vertebrates develops via similar mechanisms. Toward the end of retinal histogenesis, proliferating progenitors and newly generated cells are confined to peripheral regions of the retina. In fish and amphibians, this region is maintained after embryonic development and becomes the CMZ (ciliary margin zone). A CMZ exists in birds but compared to that of fish and amphibians this region produces much less new retina as the globe of the eye expands postnatally. At least some of the molecular mechanisms that regulate the addition of new cells in this zone appear to have been conserved from fish to birds.[well established][VHOG]
id
UBERON:0003065