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Tumor necrosis factor receptor superfamily member 6

https://identifiers.org/uniprot:P25445

Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

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Term info

Label

Tumor necrosis factor receptor superfamily member 6

Synonyms

Tumor necrosis factor receptor superfamily member 6

database cross reference

exactMatch

https://identifiers.org/uniprotQ14295, https://identifiers.org/uniprotQ14294, https://identifiers.org/uniprotQ16652, https://identifiers.org/uniprotQ14293, https://identifiers.org/uniprotB6VNV4, https://identifiers.org/uniprotQ14292, https://identifiers.org/uniprotA9UJX4, https://identifiers.org/uniprotQ5T9P1, https://identifiers.org/uniprotQ5T9P2, https://identifiers.org/uniprotTNR6_HUMAN, https://identifiers.org/uniprotQ5T9P3

inScheme

https://identifiers.org/uniprot

prefLabel

Tumor necrosis factor receptor superfamily member 6

Term relations

Subclass of:

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