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Elongation factor Tu, mitochondrial

https://identifiers.org/uniprot:P49411

Function: Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.

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Term info

Label

Elongation factor Tu, mitochondrial

Synonyms

Elongation factor Tu, mitochondrial

database cross reference

exactMatch

https://identifiers.org/uniprotEFTU_HUMAN

inScheme

https://identifiers.org/uniprot

prefLabel

Elongation factor Tu, mitochondrial

Term relations

Subclass of:

Thing