Terminology Service < Semantic Lookup Platform

Protein phosphatase 1A

https://identifiers.org/uniprot:P49443

Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

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Term info

Label

Protein phosphatase 1A

Synonyms

Protein phosphatase 1A

database cross reference

exactMatch

https://identifiers.org/uniprotPPM1A_MOUSE

inScheme

https://identifiers.org/uniprot

prefLabel

Protein phosphatase 1A

Term relations

Subclass of:

Thing