Terminology Service for NFDI4Health

Ubiquitin-conjugating enzyme E2 A

Go to external page https://identifiers.org/uniprot:P49459


Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

Term info

Label

Ubiquitin-conjugating enzyme E2 A

Synonyms
  • Ubiquitin-conjugating enzyme E2 A
database cross reference
exactMatch

https://identifiers.org/uniprotA6NFE9, https://identifiers.org/uniprotB2R7R9, https://identifiers.org/uniprotA6NMF5, https://identifiers.org/uniprotQ4TTG1, https://identifiers.org/uniprotD3DWI1, https://identifiers.org/uniprotA6NGR2, https://identifiers.org/uniprotUBE2A_HUMAN

inScheme

https://identifiers.org/uniprot

prefLabel

Ubiquitin-conjugating enzyme E2 A

Term relations

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