Terminology Service < Semantic Lookup Platform

Eukaryotic peptide chain release factor subunit 1

https://identifiers.org/uniprot:P62495

Function: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965, PubMed:24486019). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).

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Term info

Label

Eukaryotic peptide chain release factor subunit 1

Synonyms

Eukaryotic peptide chain release factor subunit 1

database cross reference

exactMatch

https://identifiers.org/uniprotQ5M7Z7, https://identifiers.org/uniprotB2R6B4, https://identifiers.org/uniprotD3DQC1, https://identifiers.org/uniprotP46055, https://identifiers.org/uniprotERF1_HUMAN

inScheme

https://identifiers.org/uniprot

prefLabel

Eukaryotic peptide chain release factor subunit 1

Term relations

Subclass of:

Thing