Terminology Service for NFDI4Health

Epithelial discoidin domain-containing receptor 1

Go to external page https://identifiers.org/uniprot:Q08345


Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Term info

Label

Epithelial discoidin domain-containing receptor 1

Synonyms
  • Epithelial discoidin domain-containing receptor 1
database cross reference
exactMatch

https://identifiers.org/uniprotDDR1_HUMAN, https://identifiers.org/uniprotQ4LE50, https://identifiers.org/uniprotB5A975, https://identifiers.org/uniprotB5A976, https://identifiers.org/uniprotQ9UD86, https://identifiers.org/uniprotQ16562, https://identifiers.org/uniprotQ9UD36, https://identifiers.org/uniprotQ14196, https://identifiers.org/uniprotQ9UD35, https://identifiers.org/uniprotQ2L6H3, https://identifiers.org/uniprotQ5ST11, https://identifiers.org/uniprotQ5ST12, https://identifiers.org/uniprotQ9UD37, https://identifiers.org/uniprotQ6NSK4, https://identifiers.org/uniprotB7Z2K0

inScheme

https://identifiers.org/uniprot

prefLabel

Epithelial discoidin domain-containing receptor 1

Term relations

Subclass of: