Terminology Service for NFDI4Health

Transcription factor GATA-4

Go to external page https://identifiers.org/uniprot:Q08369


Function: Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (By similarity).

Term info

Label

Transcription factor GATA-4

Synonyms
  • Transcription factor GATA-4
database cross reference
exactMatch

https://identifiers.org/uniprotGATA4_MOUSE, https://identifiers.org/uniprotB9EHF7, https://identifiers.org/uniprotP97491

inScheme

https://identifiers.org/uniprot

prefLabel

Transcription factor GATA-4

Term relations

Subclass of: