Terminology Service for NFDI4Health

Piezo-type mechanosensitive ion channel component 1

Go to external page https://identifiers.org/uniprot:Q0KL00


Function: Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.

Term info

Label

Piezo-type mechanosensitive ion channel component 1

Synonyms
  • Piezo-type mechanosensitive ion channel component 1
database cross reference
exactMatch

https://identifiers.org/uniprotPIEZ1_RAT

inScheme

https://identifiers.org/uniprot

prefLabel

Piezo-type mechanosensitive ion channel component 1

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