Terminology Service for NFDI4Health

UBX domain-containing protein 2B

Go to external page https://identifiers.org/uniprot:Q0KL01


Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.

Term info

Label

UBX domain-containing protein 2B

Synonyms
  • UBX domain-containing protein 2B
database cross reference
exactMatch

https://identifiers.org/uniprotQ8CCQ0, https://identifiers.org/uniprotQ8BGY8, https://identifiers.org/uniprotUBX2B_MOUSE

inScheme

https://identifiers.org/uniprot

prefLabel

UBX domain-containing protein 2B

Term relations

Subclass of: