Terminology Service for NFDI4Health

Importin subunit alpha-6

Go to external page https://identifiers.org/uniprot:Q56R16


Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9 (By similarity).

Term info

Label

Importin subunit alpha-6

Synonyms
  • Importin subunit alpha-6
database cross reference
exactMatch

https://identifiers.org/uniprotIMA6_RAT

inScheme

https://identifiers.org/uniprot

prefLabel

Importin subunit alpha-6

Term relations

Subclass of: