Voltage-dependent anion-selective channel protein 1
Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Term info
Voltage-dependent anion-selective channel protein 1
- Voltage-dependent anion-selective channel protein 1
https://identifiers.org/uniprotVDAC1_MOUSE, https://identifiers.org/uniprotB1ASZ9
https://identifiers.org/uniprot
Voltage-dependent anion-selective channel protein 1