Terminology Service for NFDI4Health

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Go to external page https://identifiers.org/uniprot:Q60967


Function: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:7493984). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (By similarity).

Term info

Label

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Synonyms
  • Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
database cross reference
exactMatch

https://identifiers.org/uniprotPAPS1_MOUSE

inScheme

https://identifiers.org/uniprot

prefLabel

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

Term relations

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