piRNA biogenesis protein EXD1
Function: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (PubMed:26669262). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).
Term info
piRNA biogenesis protein EXD1
- piRNA biogenesis protein EXD1
https://identifiers.org/uniprotEXD1_MOUSE
https://identifiers.org/uniprot
piRNA biogenesis protein EXD1