Mitofusin-1
Function: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).
Term info
Mitofusin-1
- Mitofusin-1
https://identifiers.org/uniprotB2RAR1, https://identifiers.org/uniprotD3DNR6, https://identifiers.org/uniprotO60639, https://identifiers.org/uniprotA0A0C4DFN1, https://identifiers.org/uniprotO15323, https://identifiers.org/uniprotMFN1_HUMAN, https://identifiers.org/uniprotQ9BZB5
https://identifiers.org/uniprot
Mitofusin-1