Terminology Service for NFDI4Health

Structural maintenance of chromosomes protein 1B

Go to external page https://identifiers.org/uniprot:Q8NDV3


Function: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).

Term info

Label

Structural maintenance of chromosomes protein 1B

Synonyms
  • Structural maintenance of chromosomes protein 1B
database cross reference
exactMatch

https://identifiers.org/uniprotSMC1B_HUMAN, https://identifiers.org/uniprotA0AV46, https://identifiers.org/uniprotQ6ZUF9, https://identifiers.org/uniprotQ5TIC3, https://identifiers.org/uniprotB0QY23, https://identifiers.org/uniprotB0QY24

inScheme

https://identifiers.org/uniprot

prefLabel

Structural maintenance of chromosomes protein 1B

Term relations

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