Terminology Service < Semantic Lookup Platform

All terms in BAO

Label	Id	Description
CL(renal)	BAO_0002773	[Clearance of the drug due to renal excretion.]
CL	BAO_0002759	[Clearance is the volume of plasma from which the drug is completely removed per unit time, or, alternatively, the volume of plasma that would have to lose all of the drug that it contains within a unit of time to account for an observed rate of drug elimination.]
Hoechst 33342	BAO_0000115
DNA	BAO_0000269	[DNA or deoxyribonucleic acid is the genetic material in all the living things, and some viruses. It is a polymer of nucleotides, with a backbone made of deoxyribose sugar and phosphate groups joined together by ester bonds.]
fluorescent dye	CHEBI_51121
CL(hepatic)	BAO_0002774	[Clearance of the drug due to hepatic enzyme activity and biliary excretion.]
aqueous solubility	BAO_0002775	[The ability of a chemical substance to dissolve in water.]
solubility	BAO_0002135	[The ability of a chemical substance to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution. The solubility of a given substance is dependent on the solvent used, as well as on temperature and pressure.]
culture medium	BAO_0000114	[The liquid broth used to grow cells, which is optimized for each cell type and includes additives such as growth factors, buffers, amino acids, antibiotics, etc. This information can be obtained from ATCC or found in relevant publications.]
material entity	BAO_0003116
lipid	BAO_0000171	[Lipids are a group of naturally occurring organic compounds that are soluble in nonpolar organic solvents, but insoluble in water. Examples include fatty acids, triglycerides, phospholipids, etc. Lipids function to store energy, form a component of cell membrane and as signaling molecules.]
biological macromolecule	BAO_0003111
protease activity determination	BAO_0000170	[Live cells have a conserved and constitutive protease activity which serves as a biomarker of cell viability. The live-cell protease activity is measured using a fluorogenic, cell-permeant, peptide substrate (Gly-Phe-AFC). The substrate enters intact cells, where it is cleaved by the live-cell protease activity to generate a fluorescent signal proportional to the number of living cells. The live-cell protease becomes inactive upon loss of membrane integrity and leakage into the surrounding culture medium.]
neurokinin-1 receptor antagonist	CHEBI_55350
antagonist	CHEBI_48706
substance P receptor antagonist	CHEBI_55351
low signal control	BAO_0000168	[The role played by the substrate, which is titrated without enzyme and without inhibitor. The low controls should reflect the signal expected for no enzyme activity at each substrate concentration. Depending on the composition of the inhibitor stocks, DMSO might be needed in the control wells to assure consistency across all the experiments.]
assay control	BAO_0000072	[The role of a compound that is routinely run in the same manner as the test compounds in every run of the assay. This term does not refer to the plate controls used to define the maximum and minimum responses, and they may or may not be a “literature standard” or “reference” compound. ]
membrane permeability assessment	BAO_0000167	[Live cells with intact membranes have the ability to exclude dyes that easily penetrate dead or damaged cells. Examples of the dyes include propidium iodide, 7-amino actinomycin D, and trypan blue. Cells stained with the former two can be quantified by flow cytometry, while the latter is by manual counting using hemocytometer. ]
TO-PRO3	BAO_0003051